Amphista Therapeutics to present novel mechanism of action for the degradation of BRD9 using its proprietary Targeted Glue® technology at two key upcoming scientific conferences
- Oral presentations will detail the rapid, deep and persistent degradation of BRD9 through the recruitment of DCAF16 using Amphista's Targeted Glue® technology.
Dr. Marta Carrara, Associate Director Target Discovery & Validation at Amphista, will deliver the oral presentations that describe the generation of selective and potent degraders of BRD9, an emerging target in Acute Myeloid Leukemia. Amphista's proprietary Targeted Glue catalyzes degradation via DCAF16, a relatively uncharacterised E3 ligase, and therefore has the potential to create novel TPD therapeutics for application across a wide range of indications.
These data illustrate the strength of the Company's proprietary chemistry and its Eclipsys™ platform in enabling the rational design of orally bioavailable protein degraders.
Details of presentations:
| Conference | Presentation Date and Time | Presentation Title |
|
2nd SMR Molecular Glues meeting, Stevenage, UK |
Friday 21st March, 11.50am-12.30pm GMT | Degradation of BRD9 by a novel "Targeted Glue®” |
|
5th Annual TPD and Induced Proximity Summit Europe, London, UK | Wednesday 26th March, 9.00am GMT | Rational design of a novel DCAF16-recruting BRD9 Targeted Glue® |
At Amphista Therapeutics, we are focused on transforming the lives of patients with severe diseases, including cancer and neurodegenerative disorders, through the discovery of advanced, next generation targeted protein degradation (TPD) medicines. Amphista applies its proprietary Eclipsys™ platform to generate unique, bifunctional Targeted Glue® therapeutics with a differentiated mechanism and leading drug-like properties. Our portfolio offers the potential to deliver first- and/or best-in-class therapeutics with performance characteristics beyond the limitations of CRBN and VHL-based agents. Amphista was co-founded by Advent Life Sciences and is additionally funded by a premier group of investors including Forbion, Gilde Healthcare, Novartis Venture Fund, SV's Dementia Discovery Fund and Eli Lilly. For more information, please visit: www.amphista.com
Amphista, Eclipsys, Targeted Glue, Targeted Glues and the Amphista logo are all trademarks or registered trademarks of Amphista Therapeutics Limited.
For more information please contact:
Amphista Therapeutics
John Goodall
Info@amphista.com
ICR Healthcare
Amber Fennell, Namrata Taak, Emily Johnson
Email: Amphista@icrhealthcare.com
Tel: +44 (0)20 3709 5813
