- Samsung Biologics showcases new innovative development platforms - S-AfuCHOTM and S-OptiChargeTM - at BioProcess International 2024
- New technology platforms to proactively address evolving industry trends and enable high-quality development
S-AfuCHOTM, introduced at BioProcess International 2024, is a cell line platform that can generate afucosylated antibodies that exhibit enhanced antibody-dependent cellular cytotoxity (ADCC) activity for increased therapeutic efficacy. The platform removes the core fucose from Fc N-glycans through knockout of the host (FUT8) gene to achieve higher ADCC activity while retaining desired titers, stability, and product quality (Figure 1).
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