LOS ANGELES: The defending NBA champion Denver Nuggets crashed to their first defeat of the season in an upset 110-89 loss to the Minnesota Timberwolves on Wednesday (Thursday in Manila), while Boston extended their unbeaten start with a brutal thrashing of Indiana.

Denver began the season in imperious form, building to a 4-0 start, but were stopped in their tracks after a dominant performance from the Timberwolves at Minneapolis's Target Center.

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