The gene editing performed on Chinese twins last year meant to immunize them against the human immunodeficiency virus (HIV) may have failed in its purpose and created unintended mutations, scientists said after the original research was made public for the first time.

Excerpts from the manuscript were released by the MIT Technology Review for the purpose of showing how Chinese biophysicist He Jiankui ignored ethical and scientific norms in creating the twins Lula and Nana, whose birth in late 2018 sent shockwaves through the scientific world.